Mechanisms of DNA Repair and Carcinogenesis

This team belongs to the UMR 9019 Genome Integrity and Cancers.

Lab members

Major Publications

• Oppezzo A, Bourseguin J, Renaud E, Pawlikowska P, Rosselli F. Microphthalmia transcription factor expression contributes to bone marrow failure in Fanconi anemia. J Clin Invest. 2020, 130:1377-1391.
• Brison O, El-Hilali S, Azar D, Koundrioukoff S, Schmidt M, Nähse V, Jaszczyszyn Y, Lachages AM, Dutrillaux B, Thermes C, Debatisse M, Chen CL. Transcription-mediated organization of the replication initiation program across  large genes sets common fragile sites genome-wide. Nat Commun, 2019, 10:5693.

4Rs : Replication, Repair, Recombination and ROS

This team belongs to the UMR 9019 Genome Integrity and Cancers.

Lab members

• Saïd AOUFOUCHI – Research Scientist – Group Leader
• Dorine BONTE – Assistant professeur -Paris Sud University
• Léticia KOCH- LERNER- Post doc
• Morwenna Le GUILLOU – Engineer assistant Paris Sud University
• Céline DECAUX- Master2 trainer programm UPMC
• Charlène TRILLeaud - Master1 trainer programm UPMC
• Roukia BELGADAR Undergraduate student –UPMC

Major publications since 2009

• Xavier Renaudin, Jean-Hugues Guervilly, Said Aoufouchi, and Filippo Rosselli.Proteome-wide analysis unveils a FANCA-modulated neddylation signaling pathway involved in CXCR5 membrane trafficking and cell mobility. 
• J Cell Sci. 2014 Aug 15;127(Pt 16):3546-54. doi: 10.1242/jcs.150706. Epub 2014 Jul 11.

Genome Plasticity and B cell

This group belongs to the group "TLS Polymerases: Genome Plasticity and Cancers" 

Our group associates researchers working on the coordination and regulation of DNA repair processes in B lymphocyte following AID expression and on the role of AID in B cell tumourigenesis. 

Lab members

• Patricia Kannouche (Directeur de recherche- CNRS), Manager
• Caroline Pouvelle (TCN CNRS)
• Emmanuelle Despras (Post-Doc GR)
• Sana Ahmed-Seguir (PhD student)
• Noémie Delrieu (PhD student, 4ème année ED Cancérologie, University Paris Sud)
• Yann Benureau (Engineer d’étude, GR- SIRIC)
• Mégane Bouvet (Technician, CDD-CNRS)
• Barbara Ben Yamin (Engineer assitant, CDD-CNRS)

Publications since 2008

• Sana Ahmed-Seghir, Caroline Pouvelle, Emmanuelle Despras, Agnès Cordonnier, Alain Sarasin and Patricia L Kannouche. Aberrant C-terminal Domain of Polymerase eta Targets the Functional Enzyme to the Proteosomal Degradation Pathway. DNA Repair, in revision.

Main research axes

Gustave Roussy's researchers and clinicians especially concentrate their work in the four main areas below, which combine basic research, clinical research, epidemiology and technology:

• Molecular Medicine
• Immunotherapy
• DNA Repair
• Rare Cancers