TLS Polymerases and Cancer

Publications since 2008

• Sana Ahmed-Seghir, Caroline Pouvelle, Emmanuelle Despras, Agnès Cordonnier, Alain Sarasin and Patricia L Kannouche. Aberrant C-terminal Domain of Polymerase eta Targets the Functional Enzyme to the Proteosomal Degradation Pathway. DNA Repair, in revision.
• Guervilly JH, Takedachi A, Naim V, Scaglione S, Chawhan C, Lovera Y, Despras E, Kuraoka I, Kannouche P, Rosselli F, Gaillard PH. The SLX4 Complex Is a SUMO E3 Ligase that Impacts on Replication Stress Outcome and Genome Stability. Mol Cell. 2015 Jan 8;57(1):123-37. doi: 10.1016/j.molcel.2014.11.014. Epub 2014 Dec 18.
• Opletalova K, Bourillon A, Yang W, Pouvelle C, Armier J, Despras E, Martin L, Mateus C, Robert C, Kannouche P, Soufir N, Sarasin A. Correlation of Phenotype/Genotype in a Cohort of 23 Xeroderma Pigmentosum-Variant Patients Reveals 12 New Disease-Causing POLH Mutations. Hum Mutat. 2013 Oct 15. doi:10.1002/humu.22462.
• Bacquin A, Pouvelle C, Siaud N, Perderiset M, Salomé-Desnoulez S, Tellier-Lebegue C, Lopez B, Charbonnier JB, Kannouche PL. The helicase FBH1 is tightly regulated by PCNA via CRL4(Cdt2)-mediated proteolysis in human cells. Nucleic Acids Res. 2013 May 15. [Epub ahead of print].
• Shoaib M, Kulyyassov A, Robin C, Winczura K, Tarlykov P, Despas E, Kannouche P, Ramanculov E, Lipinski M, Ogryzko V. PUB-NChIP--"in vivo biotinylation" approach to study chromatin in proximity to a protein of interest. Genome Res. 2013 Feb;23(2):331-40. doi: 10.1101/gr.134874.111. Epub 2012 Oct 4. 
• Despras E, Delrieu N, Garandeau C, Ahmed-Seghir S, Kannouche PL. Regulation of the specialized DNA polymerase eta: revisiting the biological relevance of its PCNA- and ubiquitin-binding motifs. Environ Mol Mutagen. 2012 Dec;53(9):752-65. doi: 10.1002/em.21741. Epub 2012 Oct 18. 
• Zlatanou A, Despras E, Braz-Petta T, Boubakour-Azzouz I, Pouvelle C, Stewart GS, Nakajima S, Yasui A, Ishchenko AA, Kannouche PL. The hMsh2-hMsh6 complex acts in concert with monoubiquitinated PCNA and Pol η in response to oxidative DNA damage in human cells. Mol Cell. 2011 Aug 19;43(4):649-62. doi: 10.1016/j.molcel.2011.06.023. 
• Kulyyassov A, Shoaib M, Pichugin A, Kannouche P, Ramanculov E, Lipinski M,Ogryzko V. PUB-MS: a mass spectrometry-based method to monitor protein-protein proximity in vivo. J Proteome Res. 2011 Oct 7;10(10):4416-27. doi: 10.1021/pr200189p. Epub 2011 Sep 2. 
• Tissier A, Janel-Bintz R, Coulon S, Klaile E, Kannouche P, Fuchs RP, Cordonnier AM. Crosstalk between replicative and translesional DNA polymerases: PDIP38 interacts directly with Poleta. DNA Repair (Amst). 2010 Aug 5;9(8):922-8.  doi: 10.1016/j.dnarep.2010.04.010. 
• Despras E, Daboussi F, Hyrien O, Marheineke K, Kannouche PL. ATR/Chk1 pathway  is essential for resumption of DNA synthesis and cell survival in UV-irradiated XP variant cells. Hum Mol Genet. 2010 May 1;19(9):1690-701. doi: 10.1093/hmg/ddq046. Epub 2010 Feb 1. 
• Petta TB, Nakajima S, Zlatanou A, Despras E, Couve-Privat S, Ishchenko A, Sarasin A, Yasui A, Kannouche P. Human DNA polymerase iota protects cells against oxidative stress. EMBO J. 2008 Nov 5;27(21):2883-95. doi: 10.1038/emboj.2008.210. Epub 2008 Oct 16.
• Niimi A, Brown S, Sabbioneda S, Kannouche PL, Scott A, Yasui A, Green CM, Lehmann AR. Regulation of proliferating cell nuclear antigen ubiquitination in mammalian cells. Proc Natl Acad Sci U S A. 2008 Oct 21;105(42):16125-30. doi: 10.1073/pnas.0802727105. Epub 2008 Oct 9. 
• Daboussi F, Courbet S, Benhamou S, Kannouche P, Zdzienicka MZ, Debatisse M, Lopez BS. A homologous recombination defect affects replication-fork progression in mammalian cells. J Cell Sci. 2008 Jan 15;121(Pt 2):162-6. Epub 2007 Dec 18.