DNA repair, chromatin remodeling and epigenetics
Major publications

1. Epigenetic drugs in solid tumours: lessons learned and future promises? Morel D, Jeffery D, Aspeslagh S, Almouzni G, Postel-Vinay S. Nature Reviews Clinical Oncology 2019 Sep 30. doi: 10.1038/s41571-019-0267-4 [Epub ahead of print]

DNA repair, chromatin remodeling and epigenetics

This team belongs to the UMR 981 - Molecular predictors and new targets in oncology.

Major publications

1: Dercle L, Ammari S, Roblin E, Bigorgne A, Champiat S, Taihi L, Plaian A, Hans S, Lakiss S, Tselikas L, Rouanne M, Deutsch E, Schwartz LH, Gönen M, Flynn J, Massard C, Soria JC, Robert C, Marabelle A. High serum LDH and liver metastases are the dominant predictors of primary cancer resistance to anti-PD(L)1 immunotherapy. Eur J Cancer. 2022 Dec;177:80-93. doi: 10.1016/j.ejca.2022.08.034. Epub 2022 Sep 30. PMID: 36332438.

Lab members

Françoise PORTEU - DR INSERM    
Eric SOLARY - PUPH
Nathalie DROIN - CR INSERM
Emilie ELVIRA-MATELOT - CR INSERM
Dorothée SELIMOGLU-BUET - CR (INSERM)
Lucie LAPLANE - CR CNRS
Aline RENNEVILLE, PH IGR
    
Richard DYUNGA - TR INSERM
Margot MORABITO - TR  (RP/IGR)
Séverine BADEL - TR (RP/IGR)
Margaux SEVIN - IR (RP/IGR)
        
 PELINSKI Yanis - Ph.D., University Paris Saclay
 Christophe WILLEKENS - Ph.D., University Paris Saclay
 Donia HIDAOUI - Ph.D., University Paris Saclay

Major publications

• Bencheikh L, Diop MK, Rivière J, Pierron G, Souquere S, Naimo A, Morabito M, Dussiot M, de Leeuw F, Solary E, Droin N. Dynamic gene regulation by nuclear colony-stimulating factor 1 receptor in human monocytes and macrophages. Nat Commun. 2019; 10(1):1935.

Lab members

• Salem Chouaib (DRE, Inserm)
• Jerome Thiery (CRCN, Inserm)
• Pierre Savagner (CRCN, CNRS)
• Laurence Albiges (PH, Gustave Roussy)
• Jean-Henri Bourhis (PH, Gustave Roussy)
• Jean-Paul Thiery (DR emeritus, CNRS)
• Stephane Terry (Post-Doctoral fellow, Gustave Roussy)
• Stephanie Buart (Engineer, Inserm)
• Abderemane Abdou (Technician, Inserm)
• Marie Chollat-Namy (PhD candidate, University Paris-Saclay)
• Flora Doffe (PhD candidate, University Paris-Saclay)

Major publications

• Noman MZ, Desantis G, Janji B, Hasmim M, Karray S, Dessen P, Bronte V, Chouaib S. PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation. J Exp Med. 2014 May 5;211(5):781-90.
• Noman MZ, Janji B, Hu S, Wu JC, Martelli F, Bronte V, Chouaib S. Tumor-Promoting Effects of Myeloid-Derived Suppressor Cells Are Potentiated by Hypoxia-Induced Expression of miR-210. Cancer Res. 2015 Sep 15;75(18):3771-87

Impact of tumor microenvironment on tumor resistance and its role in shaping tumor plasticity and stroma reactivity

This group belongs to the UMR 1186 - Integrative tumor immunology and immunotherapy

Lab members

• Karim Fizazi (PU-PH Univ. Paris-Saclay)
• Yohann Loriot (MD-PhD, GR)
• Anne Chauchereau (CRCN-HDR INSERM)
• Virginie Quidville (Research Engineer, GR)
• Déborah Bellet (Chargée d’études, GR)
• Ludovic Bigot (Engineer, GR)
• Sandrine Agoussi (Technician, GR)
• Jonathan Sabio (Technician, GR)
• Guiseppina Claps (Post-Doctoral fellow, GR)
• Ramdane Guemiri (Post-Doctoral fellow, GR)
• Shensi Shen (Post-Doctoral fellow, GR)
• Michaël Cerezo (Post-Doctoral fellow, GR)