Lab members

• Leaders
  Isabelle PLO-AZEVEDO (DR2 INSERM), Hana RASLOVA (DR2 INSERM)
• Researchers
  Isabelle GODIN (DR2 CNRS), William VAINCHENKER (DRE INSERM), Najet DEBILI (DRE CNRS), Jean-Luc VILLEVAL (DRE INSERM), Monika WITTNER (CR1 CNRS), Antonio DI STEFANO (CRCN INSERM), Caroline MARTY (CRCN INSERM) ), Iléana ANTONY-DEBRE (CRCN INSERM)
• Clinicians / biologists
  Rémi FAVIER (PH APHP, Christine BELLANNE (MCU-PH / Interface INSERM), Florence PASQUIER (PH IGR), Christophe MARZAC (PH IGR), Jean-Baptiste MICOL (PH IGR)
• Technicians

Major publications

• Toppaldoddi KR, da Costa Cacemiro M, Bluteau O, Panneau-Schmaltz B, Pioch A, Muller D, Villeval JL, Raslova H, Constantinescu SN, Plo I, Vainchenker W, Marty C. Rare type 1-like and type 2-like calreticulin mutants induce similar myeloproliferative neoplasms as prevalent type 1 and 2 mutants in mice. Oncogene. 2019 Mar;38(10):1651-1660.

From haematopoietic stem cell to megakaryocyte

This group belongs to the UMR 1287: Hematopoietic stem cells and the development of hematological malignancies

Our research:

Bioinformatics core facility - Lab members

• Head of the bioinformatics core facility: Marc Deloger (marc.deloger@gustaveroussy.fr)

• "Core Service" bioinformaticians (permanent employees): Thibault Dayris, M’boyba Diop, Bastien Job, Gérôme Jules-Clement, Franck Le-Layo.

• "Core Service" bioinformaticians (non-permanent employees) : Marine Aglave, Edi Tihic

Bioinformatics core facility - Activities

• Analysis of (epi)genomic / transcriptomic sequencing data (WGS / WES / TGS, RNA-seq, ChIP / ATAC-seq, Single-Cell, Long Reads)
• Data management (recovery, centralization, organization, labeling, provision / sharing)
• Support to bioinformaticians, biologists, and clinicians from Gustave Roussy
• Publication assistance (material and methods, figures, deposit of data on public databases such as GEO / SRA / EGA / dbGAP)
• Co-supervision of junior bioinformaticians (trainees, PhD students…)

Lab members

Lab head
Prof. Nathalie Chaput-Gras
Email

Lab manager
Dr Lydie Cassard

Assistant professor
Dr Marie Naigeon

Engineer
Jean Jouniaux:

Engineer
Lisa Boselli

Technician
Jonathan Grivel:

Equipments

• 1 MACSQuant 16 Cytometer – Miltenyi Biotec Inc.
• 1 CytoFLEX S base Cytometer – Beckman Coulter
• 2 GALLIOS Cytometer – Beckman Coulter
• MAGPIX Multiplexing System – Luminex B.V.
• MESO QuickPlex SQ 120 – Meso Scale Discovery (LRTI)
• GentleMACS Dissociator - Miltenyi Biotec Inc.
• Vi-CELL XR Cell Analyzer – Beckman Coulter
• xCELLigence RTCA - Agilent

Activities

The Laboratory of Immunomonitoring in Oncology (LIO), created at the end of 2014, is a translational research unit. The main objective of the laboratory is to identify blood or tumor biomarkers that can predict the response or resistance to anti-tumor immunotherapies, as well as the emergence of some immunological adverse effects that may be linked to these treatments. Another objective is to understand the mechanisms of action of anti-tumor immunotherapies.

• Pr Cécile Badoual, Dr Sophie Broutin: Responsable plateforme CRB
• Nathalie Jacques : Cadre hiérarchique plateforme CRB
• Valérie Camara-Clayette : Cadre technique plateforme CRB

CRB-tissus

• Pr Cécile Badoual : Responsable CRB-tissus
• Delphine Arnaud : Technicienne de laboratoire
• Chiraz Ayadi : Technicienne de laboratoire
• Joseph Gutierrez : Technicien de laboratoire
• Christine Machavoine : Technicienne de laboratoire

ET-Extra

• Dr Caroline Pradon : Responsable ET-Extra

Activities of the Biological Resource Centre

The Biological Resource Centre (CRB) is charged with storage of all the patient tissue samples which are considered by clinicians to be useful. All of these patients have signed consent forms and samples of their plasma, serum and whole blood are also stored. In addition the CRB keeps samples of public health importance and those collected in clinical research projects.