Metabolic plasticity in health and diseases

Major publications

• Reinhardt C, Arena G, Nedara K, Edwards R, Brenner C, Tokatlidis K, Modjtahedi N. AIF meets the CHCHD4/Mia40-dependnet mitochondrial import pathway. Biochim Biophys Acta Mol Basis Dis. 2020 Jun 1;1866(6):165746. doi: 10.1016/j.bbadis.2020.165746.
• Pervaiz S, Bellot G, Lemoine A, and Brenner C. Redox Signaling in the pathogenesis of human disease and the regulatory role of autophagy. Int Rev Cell Mol Biol. 2020, in press.
• Rao S, Mondragón L, Pranjic B, Hanada T, Stoll G, Köcher T, Zhang P, Jais A, Lercher A, Bergthaler A, Schramek D, Haigh K, Sica V, Leduc M, Modjtahedi N, Pai TP, Onji M, Uribesalgo I, Hanada R, Kozieradzki I, Koglgruber R, Cronin SJ, She Z, Quehenberger F, Popper H, Kenner L, Haigh JJ, Kepp O, Rak M, Cai K, Kroemer G, Penninger JM. AIF-regulated oxidative phosphorylation supports lung cancer development. Cell Res. 2019 Jul;29(7):579-591. doi: 10.1038/s41422-019-0181-4.
• Oudot C, Gomes A, Nicolas V, Le Gall M, Chafey P, Broussard C, Calamita G, Mastrodonato M, Gena P, Perfettini JL, Hamelin J, Lemoine A, Fischmeister R, Vieira HLA, Santos CN, Brenner C. CSRP3 Mediates Berries-Afforded Cardioprotection in Hypertension-Induced Heart Failure. J Nutr Biochemistry, 2019 DOI : 10.1016/j.jnutbio.2019.01.001
• Gomes A, Oudot C, Macià A, Foito A, Carregosa D, Stewart D, Van de Wiele T, Berry D, Motilva MJ, Brenner C and Santos CN. Berry-Enriched Diet in Salt-Sensitive Hypertensive Rats: Metabolic Fate of (Poly)Phenols and the Role of Gut Microbiota. Nutrients, 2019, 11, 2634-71.
• Rodriguez J, Zhang Y, Li T, Xie C, Sun Y, Xu Y, Zhou K, Huo K, Wang Y, Wang X, Andersson D, Ståhlberg A, Xing Q, Mallard C, Hagberg H, Modjtahedi N, Kroemer G, Blomgren K, Zhu C. Lack of the brain-specific isoform of apoptosis-inducing factor aggravates cerebral damage in a model of neonatal hypoxia-ischemia. Cell Death Dis. 2018 Dec 18;10(1):3. doi: 10.1038/s41419-018-1250-1.
• Massaad-Massade L, Boutary S, Caillaud M, Gracia C, Parola B, Gnaouiya SB, Stella B, Arpicco S, Buchy E, Desmaële D, Couvreur P, Urbinati G. New Formulation for the Delivery of Oligonucleotides Using "Clickable" siRNA-Polyisoprenoid-Conjugated Nanoparticles: Application to Cancers Harboring Fusion Oncogenes. Bioconjug Chem. 2018 Jun 20;29(6):1961-1972.
• Sun Y, Li T, Xie C, Xu Y, Zhou K, Rodriguez J, Han W, Wang X, Kroemer G, Modjtahedi N, Blomgren K, Zhu C. Haploinsufficiency in the mitochondrial protein CHCHD4 reduces brain injury in a mouse model of neonatal hypoxia-ischemia. Cell Death Dis. 2017 May 11;8(5):e2781. doi: 10.1038/cddis.2017.196.
• Azan A., Caspers P.J., Bakker Schut T.C., Roy S., Boutros C., Mateus C., Routier E., Besse B., Planchard D., Seck A., Kamsu Kom N., Tomasic G., Koljenović S., Noordhoek Hegt V., Celebic A., Texier M., Lanoy E., Eggermont A.M.M., Paci A., Robert C., Puppels G.J., L.M. Mir. A Novel Spectroscopically Determined Pharmacodynamic Biomarker for Skin Toxicity in Cancer Patients Treated with Targeted Agents. Cancer Res. 77: 557-565, 2017; DOI:10.1158/0008-5472.CAN-16-1733
• Azan A., Untereiner V., Descamps L., Merla C., Gobinet C., Breton M., Piot O. and L. M. Mir. Comprehensive Characterization of the Interaction between Pulsed Electric Fields and Live Cells by Confocal Raman Microspectroscopy. Analytical Chemistry 89, 10790-10797, 2017.
• Hanna H., Andre F.M. and L.M. Mir. Electrical control of calcium oscillations in mesenchymal stem cells using microsecond pulsed electric fields. Stem cell research and therapy, vol 8, art 91, 2017, DOI: 10.1186/s132Je mettrai87-017-0536-z
• Wang Z, Liu D, Varin A, Nicolas V, Courilleau D, Mateo P, Caubere C, Rouet P, Gomez AM, Vandecasteele G, Fischmeister R, Brenner C. A cardiac mitochondrial cAMP signaling pathway regulates calcium accumulation, permeability transition and cell death. Cell Death Dis. 7:e2198, 2016.
• Wiraswati HL, Hangen E, Sanz AB, Lam NV, Reinhardt C, Sauvat A, Mogha A, Ortiz A, Kroemer G, Modjtahedi N. Apoptosis inducing factor (AIF) mediates lethal redox stress induced by menadione. Oncotarget. 2016 Nov 22;7(47):76496-76507. doi: 10.18632/oncotarget.12562.
• Modjtahedi N, Kroemer G. CHCHD4 links AIF to the biogenesis of respiratory chain complex I. Mol Cell Oncol. 2015 Jul 29;3(2):e1074332. doi: 10.1080/23723556.2015.1074332. eCollection 2016 Mar.
• Modjtahedi N, Tokatlidis K, Dessen P, Kroemer G. Mitochondrial Proteins Containing Coiled-Coil-Helix-Coiled-Coil-Helix (CHCHD) Domains in Health and disease. Trends Biochem Sci. 2016 Mar;41(3):245-260. doi: 10.1016/j.tibs.2015.12.004.
• Modjtahedi N, Hangen E, Gonin P, Kroemer G. Metabolic epistasis among apoptosis-inducing factor and the mitochondrial import factor CHCHD4. Cell Cycle. 2015;14(17):2743-7. doi: 10.1080/15384101.2015.1068477.
• Hangen E, Féraud O, Lachkar S, Mou H, Doti N, Fimia GM, Lam NV, Zhu C, Godin I, Muller K, Chatzi A, Nuebel E, Ciccosanti F, Flamant S, Bénit P, Perfettini JL, Sauvat A, Bennaceur-Griscelli A, Ser-Le Roux K, Gonin P, Tokatlidis K, Rustin P, Piacentini M, Ruvo M, Blomgren K, Kroemer G, Modjtahedi N. Interaction between AIF and CHCHD4 Regulates Respiratory Chain Biogenesis. Mol Cell. 2015 Jun 18;58(6):1001-14. doi: 10.1016/j.molcel.2015.04.020.