Dr Jacques Grill

Dr Jacques Grill is a physician-researcher, responsible since 2011 for the Brain Tumour Programme in the Department of Child and Teenage Oncology at Gustave Roussy. He is also in charge of the clinical and translational research in this department.
 
He graduated in pediatrics from the Faculty of Medicine of the Descartes University (Necker-Enfants Malades University Hospital) and holds a PhD in Science from the Free University of Amsterdam (Netherlands). He is the coordinating investigator of several clinical studies, co-directs teaching in the master's degree in oncology and is responsible for modules in several inter-university diplomas at the University of Paris Sud.
 
Dr Grill leads the first Inserm research team (U981) dedicated exclusively to childhood gliomas and in particular to brain stem infiltrating gliomas (BSIG) and related tumours. With his team, he has been involved in numerous discoveries that are crucial to the understanding and development of new treatments for DIPG.
 
The team is developing preclinical models, 3D models (e.g. mini-brains) in order to better characterise tumour oncogenesis and to study the impact of the microenvironment on brain invasion by these tumour cells. It is also conducting research on brain tumour predisposition, ependymomas and the genomics of rare brain tumours.
 
Dr Jacques Grill has published nearly 200 referenced articles, some of which have been published in : Cancer Discovery, Cancer Cell, Nature Genetics, Nature Medicine, Lancet Oncology or Journal of Clinical Oncology.