4Rs : Replication, Repair, Recombination and ROS

Major Publications

• Oppezzo A, Bourseguin J, Renaud E, Pawlikowska P, Rosselli F. Microphthalmia transcription factor expression contributes to bone marrow failure in Fanconi anemia. J Clin Invest. 2020, 130:1377-1391.
• Brison O, El-Hilali S, Azar D, Koundrioukoff S, Schmidt M, Nähse V, Jaszczyszyn Y, Lachages AM, Dutrillaux B, Thermes C, Debatisse M, Chen CL. Transcription-mediated organization of the replication initiation program across  large genes sets common fragile sites genome-wide. Nat Commun, 2019, 10:5693.
• Blin M, Le Tallec B, Nähse V, Schmidt M, Brossas C, Millot GA, Prioleau MN, Debatisse M. Transcription-dependent regulation of replication dynamics modulates genome stability. Nat Struct Mol Biol, 2019 26:58-66.
• Leboulleux S, Dupuy C, Lacroix L, Attard M, Grimaldi S, Corre R, Ricard M, Nasr S, Berdelou A, Hadoux J, Hartl D, Terroir M, Baudin E, Schlumberger M, Al Ghuzlan A. Redifferentiation of a BRAFK601E-Mutated Poorly Differentiated Thyroid Cancer Patient with Dabrafenib and Trametinib Treatment. Thyroid, 2019, 29:735-742.
• Renaud, E., A. Barascu, and F. Rosselli. Impaired TIP60-mediated H4K16 acetylation accounts for the aberrant chromatin accumulation of 53BP1 and RAP80 in Fanconi anemia pathway-deficient cells. Nucl Acids Res, 2016, 44:648-656.
• Ameziane-El-Hassani R, Schlumberger M, Dupuy C. NADPH oxidases: new actors in  thyroid cancer? Nat Rev Endocrinol, 2016, 12:485-494.
• Ameziane-El-Hassani R, Talbot M, de Souza Dos Santos MC, Al Ghuzlan A, Hartl D, Bidart JM, De Deken X, Miot F, Diallo I, de Vathaire F, Schlumberger M, Dupuy  C. NADPH oxidase DUOX1 promotes long-term persistence of oxidative stress after an exposure to irradiation. Proc Natl Acad Sci U S A, 2015, 112(16):5051-5056.
• Nguyen, T.V., L. Riou, S. Aoufouchi, and F. Rosselli. Fanca deficiency reduces A/T transitions in somatic hypermutation and alters class switch recombination junctions in mouse B cells. J Exp Med, 2014, 211:1011-1018.
• Pawlikowska, P., P. Fouchet, W. Vainchenker, F. Rosselli, and V. Naim. 2014. Defective endomitosis during megakaryopoiesis leads to thrombocytopenia in Fanca-/- mice. Blood, 2014, 124:3613-3623.
• Naim, V., T. Wilhelm, M. Debatisse, and F. Rosselli. ERCC1 and MUS81-EME1 promote sister chromatid separation by processing late replication intermediates at common fragile sites during mitosis. Nat Cell Biol, 2013, 15:1008-1015.