Oncogenesis and tumour progression of melanoma group

This team belongs to the UMR 1279 - Tumor cell dynamics

In our group we are studying in parrallel:

• The biology of melanocytes which are pigment producing cells responsible for skin color
• The biology of cutaneous melanoma, which derives fromm melanocytes.

Using a comprehensive approach, we strive to identify mutations responsible for melanoma transformation and genes involved in metastasis.

Tumour Immunology and anti-cancer immunotherapy unit

This unit is an Inserm, Gustave Roussy and Paris-Saclay University Mixed Research Unit.

The unit "Tumour immunology and anti-cancer immunotherapy" consists of the following research teams:

UMR 981 - Molecular predictors and new targets in oncology

Directed by Prof.Fabrice André, this Mixed Research Unit (Inserm - Gustave Roussy - University of Paris Sud) is a multiple team unit:

UMR 1170 - Transcriptional and epigenetic control of Malignant Hematopoiesis

BIOMAPS

BIOMAPS is a CNRS – Gustave Roussy – University of Paris-South Mixed Research Unit

This research unit is located on three sites:

Physiology and Molecular Pathology of Endogenous and Infectious Retroviruses

This Research Unit is composed of the "Physiology and Molecular Pathology of Endogenous and Infectious Retroviruses" team.

The Unit's work, historically focused on retroelements and retroviruses, has made significant contributions to:

Lab members

• Fathia Mami-Chouaib (DR1 INSERM): group leader
• Pascale Leroy (CRCN, CNRS)
• Julien Adam (PH, IGR)
• Stéphanie Corgnac (Post-Doc, IGR)
• Marine Leclerc (Post-Doc, IGR)
• Inès Malenica (Post-Doc, INSERM)
• Isabelle Tihy (PhD student, Paris XI)
• Gwendoline Gros (AI, INSERM)
• Jamila Kacher (IE, CDD, INSERM)
• Laetitia Grynszpan (TCN, CDD, IGR)
• Vincent de Montpreville (PH, Centre Chirurgical Marie Lannelongue)
• Clara Coelho Basto (M2, Paris XI)

Major publications

1. DJENIDI F, ADAM J, GOUBAR A, DURGEAU A, MEURICE G, DE MONTPREVILLE V, VALIDIRE P, BESSE B and MAMI-CHOUAIB F. CD8⁺/CD103⁺ tumor-infiltrating lymphocytes are tumor-specific tissue-resident memory T cells and a prognostic factor for survival in lung cancer patients. J Immunol. 2015 Apr 1;194(7):3475-86.

Researchers

Dr. Michele MONDINI (CRCN, INSERM)
Dr. Charlotte ROBERT (MCU, Paris Saclay, Gustave Roussy)

Doctors/Pharmacists/Physicists

Major Publications

• Meziani L, Gerbé de Thoré M, Hamon P, Bockel S, Andrade Louzada A, Clemenson C, Corré E, Liu W , Dupuy C, Mondini M, Deutsch E. “Dual oxidase 1 limits the IFNγ-associated antitumor effect of macrophages” J Immunother Cancer 2020