Advanced T cell therapy: lab members

• Laurie Menger PhD, HDR CRCN INSERM
• Aurélien Sutra Del Galy MD PhD, Data scientist
• Marguerite Laprie Sentenac, PharmD, PhD student
• Albane Simon, PhD student
• Chloe Slater, PhD student, collab Massachusetts General Hospital USA
• Chuang Dong, Data scientist
• Laetitia Perrin, Engineer
• Janany Kandiah, Engineer

Advanced T cell therapy - Major publications

• Ablation of FAS confers allogeneic CD3^- CAR T cells with resistance to rejection by T cells and natural killer cells. Menegatti S, Lopez-Cobo S, Sutra Del Galy A, Fuentealba J, Silva L, Perrin L, Heurtebise-Chrétien S, Pottez-Jouatte V, Darbois A, Burgdorf N, Privat AL, Simon A, Laprie-Sentenac M, Saitakis M, Wick B, Webber BR, Moriarity BS, Lantz O, Amigorena S, Menger L. Nat Biomed Eng. 2024 Nov 18. doi: 10.1038/s41551-024-01282-8.

Advanced T cell therapy : current research

This research team belongs to the UMR 1015 - Tumor immunology and immunotherapies

We develop genome editing approaches derived from CRISPR-cas9 technology (inactivation, activation, base editing, genome-wide) to understand the biology of T cells but also improve the composition, functionality, and persistence of therapeutic cell products, CAR-T, and TILs (tumor-infiltrating lymphocytes).

Research - Call for Applications 2025

Gustave Roussy Prize

The Institute is launching the Gustave Roussy Prize to mark the 150th anniversary of the birth of its visionary founder.
 

Villejuif, le 6 novembre 2024

(Epi)genome replication - Publications

• Fajri N, Petryk N^#. Monitoring and quantifying replication fork dynamics with high-throughput methods. Commun Biol. 2024 Jun 14;7(1):729. doi: 10.1038/s42003-024-06412-1.
• Wu X*, Liu Y*, Daubenton-Carafa Y ; Thermes C ; Chen CL#, Hyrien O#, Petryk N#. Genome-wide measurement of DNA replication fork directionality and quantification of DNA replication initiation and termination with Okazaki fragment sequencing. Nature protocols. 2023 Apr;18(4):1260-1295. doi: 10.1038/s41596-022-00793-5.

(Epi)genome replication: research topics

This team belongs to the UMR 9019 Genome Integrity and Cancers.

Our goal is to understand how cells copy both their DNA and epigenome during division. Disruptions in this process can lead to changes in cell identity and contribute to cancer.

Tumour immunology and anti-cancer immunotherapy

The team belongs to the UMR 1015 - Tumour immunology and anti-cancer immunotherapy

The unit "Tumour immunology and anti-cancer immunotherapy" consists of four groups:

Organisation du Centre de Ressources Biologiques

La Biobanque de Gustave Roussy est structurée en 2 modules :

Présentation du Centre de Ressources Biologiques

Le Centre de Ressources Biologiques (CRB) de Gustave Roussy a été créé en 2001 afin de centraliser la gestion de ressources biologiques issues du soin et à des fins de recherche, et d’assurer ainsi une prise en charge technique et une traçabilité optimales des échantillons et de leurs données associées.

En 2011, la gestion des ressources biologiques fluides issues des essais cliniques a été intégrée au CRB, élargissant le périmètre d’activité du service.