Genome dynamics and instability

Genome dynamics and instability: major publications

• Pellerin D, Del Gobbo GF, Couse M, Dolzhenko E, Nageshwaran SK, Cheung WA, Xu IRL, Dicaire MJ, Spurdens G, Matos-Rodrigues G, Stevanovski I, Scriba CK, Rebelo A, Roth V, Wandzel M, Bonnet C, Ashton C, Agarwal A, Peter C, Hasson D, Tsankova NM, Dewar K, Lamont PJ, Laing NG, Renaud M, Houlden H, Synofzik M, Usdin K, Nussenzweig A, Napierala M, Chen Z, Jiang H, Deveson IW, Ravenscroft G, Akbarian S, Eberle MA, Boycott KM, Pastinen T; All of Us Research Program Long Read Working Group; Brais B, Zuchner S, Danzi MC. A common flanking variant is associated with enhanced stability of the FGF14-SCA27B repeat locus. Nat Genet. 2024 Jul;56(7):1366-1370. doi: 10.1038/s41588-024-01808-5. Epub 2024 Jun 27. PMID: 38937606; PMCID: PMC11440897.
• Pavani R, Tripathi V, Vrtis KB, Zong D, Chari R, Callen E, Pankajam AV, Zhen G, Matos-Rodrigues G, Yang J, Wu S, Reginato G, Wu W, Cejka P, Walter JC, Nussenzweig A. Structure and repair of replication-coupled DNA breaks. Science. 2024 Aug 16;385(6710):eado3867. doi: 10.1126/science.ado3867. Epub 2024 Aug 16. PMID: 38900911; PMCID: PMC11620331.
• Hisey JA, Radchenko EA, Mandel NH, McGinty RJ, Matos-Rodrigues G, Rastokina A, Masnovo C, Ceschi S, Hernandez A, Nussenzweig A, Mirkin SM. Nucleic Acids Research. 2024 May 8Pathogenic CANVAS (AAGGG)n repeats stall DNA replication due to the formation of alternative DNA structures. doi: 10.1093/nar/gkae124. PMID: 38381906.
• Matos-Rodrigues G, Hisey JA, Nussenzweig A, Mirkin SM. Molecular Cell. 2023 Oct 19. Detection of alternative DNA structures and its implications for human disease. doi: 10.1016/j.molcel.2023.08.018. PMID: 37863029.
• Matos-Rodrigues G, Barroca V, Muhammad AA, Dardillac E, Allouch A, Koundrioukoff S, Lewandowski D, Despras E, Guirouilh-Barbat J, Frappart L, Kannouche P, Dupaigne P, Le Cam E, Perfettini JL, Romeo PH, Debatisse M, Jasin M, Livera G, Martini E, Lopez BS. EMBO Journal. 2023 Oct 16. In vivo reduction of RAD51-mediated homologous recombination triggers aging but impairs oncogenesis. doi: 10.15252/embj.2022110844. PMID: 37661798.
• Ragu S, Droin N, Matos-Rodrigues G, Barascu A, Caillat S, Zarkovic G, Siberchicot C, Dardillac E, Gelot C, Guirouilh-Barbat J, Radicella JP, Ishchenko AA, Ravanat JL, Solary E, Lopez BS. Cell Death Differrentiation. 2023 May 30. A noncanonical response to replication stress protects genome stability through ROS production, in an adaptive manner. doi: 10.1038/s41418-023-01141-0. PMID: 36869180.
• Wang D, Wu W, Callen E, Pavani R, Zolnerowich N, Kodali S, Zong D, Wong N, Noriega S, Nathan WJ, Matos-Rodrigues G, Chari R, Kruhlak MJ, Livak F, Ward M, Caldecott K, Di Stefano B, Nussenzweig A. Science. 2022 Dec 2. Active DNA demethylation promotes cell fate specification and the DNA damage response. doi: 10.1126/science.add9838. PMID: 36454826.
• Matos-Rodrigues G, van Wietmarschen N, Wu W, Tripathi V, Koussa NC, Pavani R, Nathan WJ, Callen E, Belinky F, Mohammed A, Napierala M, Usdin K, Ansari AZ, Mirkin SM, Nussenzweig A. Molecular Cell. 2022 Oct 6. S1-END-seq reveals DNA secondary structures in human cells. doi: 10.1016/j.molcel.2022.08.007. PMID: 36075220.
• Matos-Rodrigues G, Guirouilh-Barbat J, Martini E, Lopez BS. NAR Cancer. 2021 May 17. Homologous recombination, cancer and the 'RAD51 paradox'. doi: 10.1093/narcan/zcab016. PMID: 34316706.
• Matos-Rodrigues GE, Grigaravicius P, Lopez BS, Hofmann TG, Frappart PO, Martins RAP. Cell Death Disease. 2020 Oct 28. ATRIP protects progenitor cells against DNA damage in vivo. doi: 10.1038/s41419-020-03090-9. PMID: 33110058.